Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity
Research article (Peer reviewed)
Sara Wernersson
Department of Anatomy, Physiology and Biochemistry
Faculty of Veterinary Medicine and Animal Sciences
Email: Sara.Wernersson@slu.se
ORCID: 0000-0003-3067-7875
Publications
2023
Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity
Research article (Peer reviewed)
Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
Research article (Peer reviewed)
2022
Targeting the carboxypeptidase activity: a promising strategy for asthma treatment
Conference abstract
Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses
Research article (Peer reviewed)
Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight
Review article (Peer reviewed)
Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function
Review article (Peer reviewed)
Composition and short-term stability of gut microbiota in lean and spontaneously overweight healthy Labrador retriever dogs
Research article (Peer reviewed)
Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases
Research article (Peer reviewed)
2021
The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases
Review article (Peer reviewed)
Carboxypeptidase inhibition by NvCI suppresses airway hyperreactivity in a mouse asthma model
Research article (Peer reviewed)
2020
Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium
Letter (Peer reviewed)
2019
Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs
Research article (Peer reviewed)
Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs
Research article (Peer reviewed)
2018
Differences in postprandial metabolites related to lipid metabolism between lean and overweight Labrador Retriever dogs
Conference abstract
2017
Plasma metabolomics reveals lowered carnitine concentrations in overweight Labrador Retriever dogs
Conference abstract (Peer reviewed)
Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents
Research article (Peer reviewed)
The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge
Research article (Peer reviewed)
2016
IL-6 and IL-17A degradation by mast cells is mediated by a serglycin:serine protease axis
Research article (Peer reviewed)
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs
Research article (Peer reviewed)
Metabolic and Hormonal Response to a Feed-challenge Test in Lean and Overweight Dogs
Research article (Peer reviewed)
Increased Bone Mass in Female Mice Lacking Mast Cell Chymase
Research article (Peer reviewed)
Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis
Research article (Peer reviewed)
2015
Testosterone and anti-Müllerian-hormone (AMH) in lean and overweight male Labrador Retrievers
Conference abstract
Serum concentrations of C-reactive protein (CRP) in lean and overweight dogs
Conference abstract
Metabolic and hormonal response to a feed-challenge test in lean and overweight dogs
Conference abstract (Peer reviewed)
Induction of mast cell apoptosis by a novel secretory granule-mediated pathway
Book chapter (Peer reviewed)
Pathogenic Escherichia coli and lipopolysaccharide enhance the expression of IL-8, CXCL5, and CXCL10 in canine endometrial stromal cells
Research article (Peer reviewed)
The Role of Heparanase in Pulmonary Cell Recruitment in Response to an Allergic but Not Non-Allergic Stimulus
Research article (Peer reviewed)
New findings can improve hay-fever therapy
Other publication
2014
Urine metabolite profiles in normal weight and overweight dogs
Conference abstract (Peer reviewed)
Airway mast cells and lymphocytes from horses are sensitive to cell death induced by lysosomal membrane permeabilization
Other publication (Peer reviewed)
Metabolic and hormonal response to a feed-challenge test in lean and overweight dogs
Conference abstract
Mast cell secretory granules: armed for battle
Review article (Peer reviewed)
2013
Interleukin-6 degradation by mast cells is mediated by serglycin-dependent serine proteases
Conference abstract
Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis
Research article (Peer reviewed)
Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation
Research article (Peer reviewed)
2012
M-OP-022 Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist
Conference abstract
Cytokines as immunological markers for systemic inflammation in dogs with pyometra
Other publication (Peer reviewed)
Human Cord Blood Derived Immature Basophils Show Dual Characteristics, Expressing Both Basophil and Eosinophil Associated Proteins
Research article (Peer reviewed)
Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist
Research article (Peer reviewed)
Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis
Research article (Peer reviewed)
Cytokines as Immunological Markers for Systemic Inflammation in Dogs with Pyometra
Research article (Peer reviewed)
2011
Lysosomal Membrane Permeabilization Induces Cell Death in Human Mast Cells
Research article (Peer reviewed)
A Role for Serglycin Proteoglycan in Mast Cell Apoptosis Induced by a Secretory Granule-mediated Pathway
Research article (Peer reviewed)
2010
PP-020-09 Protective role of mast cell chymase in house dust mite induced allergic airway inflammation
Conference abstract (Peer reviewed)
Serglycin-independent Release of Active Mast Cell Proteases in Response to Toxoplasma gondii Infection
Research article (Peer reviewed)
Mast cell proteases: multifaceted regulators of inflammatory disease
Review article (Peer reviewed)
Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase
Research article (Peer reviewed)
2009
A protective role of the murine chymase, mouse mast cell protease 4 (mMCP-4), in a model of allergic inflammation
Conference abstract (Peer reviewed)