Srinivas Akula

Publications

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2023

Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Aybay, Erdem; Elkhalifa, Mamoun; Akula, Srinivas et al. 2023. DOI: 10.1016/j.dci.2023.104920

Research article (Peer reviewed)

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Aybay, Erdem; Ryu, Jinhye; Fu, Zhirong et al. 2023. DOI: 10.3389/fimmu.2023.1211295

Research article (Peer reviewed)

Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

Allam, Venkata Sita Rama Raju; Waern, Ida; Taha, Sowsan et al. 2023. DOI: 10.3389/fimmu.2023.1136780

Research article (Peer reviewed)

2022

Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

Akula, Srinivas; Hellman, Lars; Aviles, Francesc Xavier et al. 2022. DOI: 10.1016/j.dci.2021.104273

Research article (Peer reviewed)

The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

Lara, Sandra; Akula, Srinivas; Fu, Zhirong et al. 2022. DOI: 10.3390/ijms23073890

Research article (Peer reviewed)

Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra et al. 2022. DOI: 10.3390/ijms23031185

Research article (Peer reviewed)

Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin et al. 2022. DOI: 10.3390/ijms23105818

Research article (Peer reviewed)

Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function

Hellman, Lars; Akula, Srinivas; Fu, Zhirong et al. 2022. DOI: 10.3389/fimmu.2022.918305

Review article (Peer reviewed)

Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

Akula, Srinivas; Riihimäki, Miia; Waern, Ida et al. 2022. DOI: 10.3390/ijms232213976

Research article (Peer reviewed)

2021

The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases

Akula, Srinivas; Fu, Zhirong; Wernersson, Sara et al. 2021. DOI: 10.3390/ijms222010975

Review article (Peer reviewed)

Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity

Fu, Zhirong; Akula, Srinivas; Qiao, Chang et al. 2021. DOI: 10.1371/journal.pone.0252624

Research article (Peer reviewed)

Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al. 2021. DOI: 10.1515/hsz-2020-0386

Research article (Peer reviewed)

Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas et al. 2021. DOI: 10.1016/j.dci.2021.104324

Research article (Peer reviewed)

Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al. 2021. DOI: 10.1016/j.dci.2021.104337

Research article (Peer reviewed)

Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al. 2021. DOI: 10.3390/ijms222312627

Research article (Peer reviewed)

2020

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al. 2020. DOI: 10.3390/ijms21020651

Research article (Peer reviewed)

Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

Teufelberger, Andrea R.; Van Nevel, Sharon; Hulpiau, Paco et al. 2020. DOI: 10.3389/fimmu.2020.582044

Research article (Peer reviewed)

Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells

Berglund, Petter; Akula, Srinivas; Fu, Zhirong et al. 2020. DOI: 10.3390/ijms21228546

Research article (Peer reviewed)

Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al. 2020. DOI: 10.3390/ijms21010319

Research article (Peer reviewed)

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong et al. 2020. DOI: 10.3390/cells9092118

Research article (Peer reviewed)

Protective role of mouse mast cell tryptase Mcpt6 in melanoma

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie et al. 2020. DOI: 10.1111/pcmr.12859

Research article (Peer reviewed)

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong et al. 2020. DOI: 10.3390/cells9010211

Research article (Peer reviewed)

2019

Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases

Yuan Zhongwei; Akula, Srinivas; Fu, Zhirong et al. 2019. DOI: 10.3390/ijms20246340

Research article (Peer reviewed)

Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al. 2019. DOI: 10.1016/j.dci.2018.11.019

Research article (Peer reviewed)

Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al. 2019. DOI: 10.3390/ijms20205147

Research article (Peer reviewed)

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