Research article2025Peer reviewedOpen access
Exploring a pico-well based scRNA-seq method (HIVE) for simplified processing of equine bronchoalveolar lavage cells
Fegraeus, Kim; Riihimaki, Miia; Nordlund, Jessica et al.
Publications
2025
2024
Research article2024Peer reviewedOpen access
Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+and CD8+T Cells, and Skin Mast Cells by Quantitative Transcriptomics
Akula, Srinivas; Alvarado-Vazquez, Abigail; Enriquez, Erika Haide Mendez et al.
Conference abstract2024Peer reviewed
Quantitative transcriptome analysis of purified equine mast cells identifies a dominant mucosal mast cell population
Akula, Srinivas; Riihimaki, Miia; Waern, Ida et al.
Research article2024Peer reviewedOpen access
Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology
Akula, Srinivas; Tripathi, Shiva Raj; Franke, Kristin et al.
Research article2024Peer reviewedOpen access
Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
Allam, Venkata Sita Rama Raju; Akula, Srinivas; Waern, Ida et al.
Research article2024Peer reviewedOpen access
Disruption of the mast cell carboxypeptidase A3 gene does not attenuate airway inflammation and hyperresponsiveness in two mouse models of asthma
Waern, Ida; Akula, Srinivas; Allam, Venkata Sita Rama Raju et al.
2023
Research article2023Peer reviewedOpen access
Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity
Aybay, Erdem; Elkhalifa, Mamoun; Akula, Srinivas et al.
Research article2023Peer reviewedOpen access
Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity
Aybay, Erdem; Ryu, Jinhye; Fu, Zhirong et al.
Research article2023Peer reviewedOpen access
Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
Allam, Venkata Sita Rama Raju; Waern, Ida; Taha, Sowsan et al.
Research article2023Peer reviewedOpen access
Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma
Riihimaki, Miia; Fegraeus, Kim; Nordlund, Jessica et al.
2022
Research article2022Peer reviewedOpen access
Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation
Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin et al.
Research article2022Peer reviewedOpen access
Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes
Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al.
Research article2022Peer reviewedOpen access
Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases
Akula, Srinivas; Hellman, Lars; Aviles, Francesc Xavier et al.
Research article2022Peer reviewedOpen access
The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation
Lara, Sandra; Akula, Srinivas; Fu, Zhirong et al.
Research article2022Peer reviewedOpen access
Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
Paivandy, Aida; Akula, Srinivas; Lara, Sandra et al.
Review article2022Peer reviewedOpen access
Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function
Hellman, Lars; Akula, Srinivas; Fu, Zhirong et al.
Research article2022Peer reviewedOpen access
Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses
Akula, Srinivas; Riihimäki, Miia; Waern, Ida et al.
Research article2022Peer reviewedOpen access
Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases
Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas et al.
2021
Research article2021Peer reviewedOpen access
Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al.
Research article2021Peer reviewedOpen access
Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases
Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al.
Research article2021Peer reviewedOpen access
Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity
Fu, Zhirong; Akula, Srinivas; Qiao, Chang et al.
Review article2021Peer reviewedOpen access
The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases
Akula, Srinivas; Fu, Zhirong; Wernersson, Sara et al.
2020
Research article2020Peer reviewedOpen access
Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3
Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al.
Research article2020Peer reviewedOpen access
Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33
Teufelberger, Andrea R.; Van Nevel, Sharon; Hulpiau, Paco et al.
Research article2020Peer reviewedOpen access
Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
Berglund, Petter; Akula, Srinivas; Fu, Zhirong et al.