Research article2024Peer reviewedOpen access
Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology
Akula, Srinivas; Tripathi, Shiva Raj; Franke, Kristin et al.
Publications
2024
Research article2024Peer reviewedOpen access
Disruption of the mast cell carboxypeptidase A3 gene does not attenuate airway inflammation and hyperresponsiveness in two mouse models of asthma
Waern, Ida; Akula, Srinivas; Allam, Venkata Sita Rama Raju et al.
Research article2024Peer reviewedOpen access
Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
Allam, Venkata Sita Rama Raju; Akula, Srinivas; Waern, Ida et al.
2023
Research article2023Peer reviewedOpen access
Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity
Aybay, Erdem; Elkhalifa, Mamoun; Akula, Srinivas et al.
Research article2023Peer reviewedOpen access
Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity
Aybay, Erdem; Ryu, Jinhye; Fu, Zhirong et al.
Research article2023Peer reviewedOpen access
Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
Allam, Venkata Sita Rama Raju; Waern, Ida; Taha, Sowsan et al.
Research article2023Peer reviewedOpen access
Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma
Riihimaki, Miia; Fegraeus, Kim; Nordlund, Jessica et al.
2022
Research article2022Peer reviewedOpen access
Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases
Akula, Srinivas; Hellman, Lars; Aviles, Francesc Xavier et al.
Research article2022Peer reviewedOpen access
The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation
Lara, Sandra; Akula, Srinivas; Fu, Zhirong et al.
Research article2022Peer reviewedOpen access
Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
Paivandy, Aida; Akula, Srinivas; Lara, Sandra et al.
Research article2022Peer reviewedOpen access
Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation
Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin et al.
Review article2022Peer reviewedOpen access
Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function
Hellman, Lars; Akula, Srinivas; Fu, Zhirong et al.
Research article2022Peer reviewedOpen access
Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses
Akula, Srinivas; Riihimäki, Miia; Waern, Ida et al.
Research article2022Peer reviewedOpen access
Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases
Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas et al.
Research article2022Peer reviewedOpen access
Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes
Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al.
2021
Review article2021Peer reviewedOpen access
The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases
Akula, Srinivas; Fu, Zhirong; Wernersson, Sara et al.
Research article2021Peer reviewedOpen access
Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity
Fu, Zhirong; Akula, Srinivas; Qiao, Chang et al.
Research article2021Peer reviewedOpen access
Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al.
Research article2021Peer reviewedOpen access
Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases
Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al.
2020
Research article2020Peer reviewedOpen access
Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3
Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al.
Research article2020Peer reviewedOpen access
Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33
Teufelberger, Andrea R.; Van Nevel, Sharon; Hulpiau, Paco et al.
Research article2020Peer reviewedOpen access
Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
Berglund, Petter; Akula, Srinivas; Fu, Zhirong et al.
Research article2020Peer reviewedOpen access
Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme
Fu, Zhirong; Akula, Srinivas; Thorpe, Michael et al.
Research article2020Peer reviewedOpen access
How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells
Akula, Srinivas; Paivandy, Aida; Fu, Zhirong et al.
Research article2020Peer reviewedOpen access
Protective role of mouse mast cell tryptase Mcpt6 in melanoma
Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie et al.