A Dual Biomarker TK1 Protein and CA125 or HE4-Based Algorithm as a Better Diagnostic Tool than ROMA Index in Early Detection of Ovarian Cancer
Research article (Peer reviewed)
Staffan Eriksson
Department of Anatomy, Physiology and Biochemistry
Faculty of Veterinary Medicine and Animal Sciences
Email: Staffan.Eriksson@slu.se
Publications
2023
A monoclonal antibody-based sandwich ELISA for measuring canine Thymidine kinase 1 protein and its role as biomarker in canine lymphoma
Research article (Peer reviewed)
Clinical significance of the TK1 specific activity in the early detection of ovarian cancer
Research article (Peer reviewed)
2022
Structural and functional analysis of human thymidylate kinase isoforms
Research article (Peer reviewed)
Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders
Research article (Peer reviewed)
Mutational analyses of human thymidine kinase 2 reveal key residues in ATP-Mg2+ binding and catalysis
Research article (Peer reviewed)
Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies
Research article (Peer reviewed)
Analytical and clinical characterization of an optimized dual monoclonal sandwich ELISA for the quantification of thymidine kinase 1 (TK1) protein in human blood samples
Research article (Peer reviewed)
Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase
Research article (Peer reviewed)
2021
Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker
Research article (Peer reviewed)
Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma
Research article (Peer reviewed)
Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity
Research article (Peer reviewed)
Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma
Research article (Peer reviewed)
Blood biomarker algorithms for the diagnosis of mycoplasma pneumoniae respiratory infections
Research article (Peer reviewed)
2020
Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency
Research article (Peer reviewed)
Identification of a novel thymidylate kinase activity
Research article (Peer reviewed)
The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs
Research article (Peer reviewed)
AroCell TK 210 ELISA for determination of TK1 protein: age-related reference ranges and comparison with other TK1 assays
Research article (Peer reviewed)
2019
The combination of AroCell TK 210 ELISA with Prostate Health Index or prostate-specific antigen density can improve the ability to differentiate prostate cancer from noncancerous conditions
Research article (Peer reviewed)
2018
Doxorubicin effects on leukemia and breast cancer cells in culture on the TK1 protein levels using AroCell TK 210 ELISA: a tool for drug development
Research article (Peer reviewed)
Negative Cooperative Binding of Thymidine, Ordered Substrate Binding, and Product Release of Human Mitochondrial Thymidine Kinase 2 Explain Its Complex Kinetic Properties and Physiological Functions
Research article (Peer reviewed)
2017
Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker
Research article (Peer reviewed)
2016
A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease
Research article (Peer reviewed)
2015
The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling
Review article (Peer reviewed)
A New Sandwich ELISA for Quantification of Thymidine Kinase 1 Protein Levels in Sera from Dogs with Different Malignancies Can Aid in Disease Management : Dog TK1-ELISA
Research article (Peer reviewed)
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