Moazzami, Ali
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
Abstract
Public health authorities recommend all fertile women to increase their folate intake to 400 mu g/d by eating folate-rich foods or by taking a folic acid supplement to protect against neural tube defects. In a previous study it was shown that folate-rich foods improved folate blood status as effectively as folic acid supplementation. The aim of the present study was to investigate, using NMR metabolomics, the effects of an intervention with a synthetic folic acid supplement v. native food folate on the profile of plasma metabolites. Healthy women with normal folate status received, in parallel, 500 mu g/d synthetic folic acid from a supplement (n 18), 250 mu g/d folate from intervention foods (n 19), or no additional folate (0 mu g/d) through a portion of apple juice (n 20). The metabolic profile of plasma was measured using H-1-NMR in fasted blood drawn at baseline and after 12 weeks of intervention. Metabolic differences between the groups at baseline and after intervention were assessed using a univariate statistical approach (P
Keywords
Folic acid; Folate; Dietary interventions; One-carbon metabolism; Metabolomics
Published in
Journal of nutritional science
2018, volume: 7, article number: e32
Publisher: CAMBRIDGE UNIV PRESS
SLU Authors
UKÄ Subject classification
Nutrition and Dietetics
Publication identifier
- DOI: https://doi.org/10.1017/jns.2018.22
Permanent link to this page (URI)
https://res.slu.se/id/publ/105551