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Abstract

BackgroundProxies are mathematical calculations based on fasting glucose and/or insulin concentrations developed to allow prediction of insulin sensitivity (IS) and beta -cell response. These proxies have not been evaluated in horses with insulin dysregulation. The first objective of this study was to evaluate how fasting insulin (FI) and proxies for IS (1/Insulin, reciprocal of the square root of insulin (RISQI) and the quantitative insulin sensitivity check index (QUICKI)) and beta -cell response (the modified insulin-to-glucose ratio (MIRG) and the homeostatic model assessment of beta -cell function (HOMA-beta)) were correlated to measures of IS (M index) using the euglycemic hyperinsulinemic clamp (EHC) in horses with insulin resistance (IR) and normal IS. A second objective was to evaluate the repeatability of FI and proxies in horses based on sampling on consecutive days. The last objective was to investigate the most appropriate cut-off value for the proxies and FI.ResultsThirty-four horses were categorized as IR and 26 as IS based on the M index. The proxies and FI had coefficients of variation (CVs)= 0.89). All proxies and FI were good predictors of the M index (r=0.76-0.85; P

Keywords

Endocrine; Equine metabolic syndrome; Beta-cell response; Insulin dysregulation; Insulin resistance

Published in

BMC Veterinary Research
2021, volume: 17, number: 1, article number: 78
Publisher: BMC

SLU Authors

UKÄ Subject classification

Clinical Science

Publication identifier

  • DOI: https://doi.org/10.1186/s12917-021-02781-5

Permanent link to this page (URI)

https://res.slu.se/id/publ/111006