Kindberg, Jonas
- Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences
- Norwegian Institute for Nature Research (NINA)
Abstract
Brown bears (Ursus arctos) hibernate for 5-6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9-107.9) vs 782.3, IQR (422.8-1586.0; p
Published in
Scientific Reports
2021, volume: 11, number: 1, article number: 12120
Publisher: NATURE RESEARCH
SLU Authors
Global goals (SDG)
SDG3 Good health and well-being
UKÄ Subject classification
Clinical Science
Publication identifier
- DOI: https://doi.org/10.1038/s41598-021-91679-1
Permanent link to this page (URI)
https://res.slu.se/id/publ/113047