Ma, Yuan
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
Abstract
Endoreplication is an evolutionarily conserved mechanism for increasing nuclear DNA content (ploidy). Ploidy frequently scales with final cell and organ size, suggesting a key role for endoreplication in these processes. However, exceptions exist, and, consequently, the endoreplication-size nexus remains enigmatic. Here, we show that prolonged tissue folding at the apical hook in Arabidopsis requires endoreplication asymmetry under the control of an auxin gradient. We identify a molecular pathway linking endoreplication levels to cell size through cell wall remodeling and stiffness modulation. We find that endoreplication is not only permissive for growth: Endoreplication reduction enhances wall stiffening, actively reducing cell size. The cell wall integrity kinase THESEUS plays a key role in this feedback loop. Our data thus explain the nonlinearity between ploidy levels and size while also providing a molecular mechanism linking mechanochemical signaling with endore-plication-mediated dynamic control of cell growth.
Published in
Science Advances
2022, volume: 8, number: 49, article number: eabq2047
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
SLU Authors
Aryal, Bibek
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
Bhalerao, Rishikesh P.
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
UKÄ Subject classification
Cell Biology
Publication identifier
- DOI: https://doi.org/10.1126/sciadv.abq2047
Permanent link to this page (URI)
https://res.slu.se/id/publ/121466