Bone Biomarker in Feedlot Cattle from Two Different Production Systems

Abstract

The rapid growth rate in feedlot cattle is likely to promote joint abnormalities like osteochondrosis dissecans (OCD) and osteoarthritis (OA) with subsequent lameness. We have identified a small leucine-rich repeat proteoglycan (SLRP) biomarker at cleavage site 262GLGHNQIRM (BGN262) arising from the fragmentation of biglycan (BGN) in subchondral bone associated with OA. With a validated custom-made ELISA, BGN262 has been quantified in serum from cattle. The concentration of BGN262 in serum from cattle raised in the conventional and all-natural production systems increased at harvest compared to the starting period. The limitation of the study is the small sample size. However, the promising results encourage a further evaluation of BGN262 and its potential as a biomarker for subchondral bone pathology in cattle.

Keywords

Osteochondrosis; Osteoarthritis; Lameness; Cattle; Biglycan; Biomarker

Published in

Food science & nutrition research
2023, volume: 6, number: 2

SLU Authors

• Lützelschwab, Claudia

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Adepu, Saritha

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Ekman, Stina

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Skiöldebrand, Eva

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Clinical Science

Permanent link to this page (URI)

https://res.slu.se/id/publ/127602