Targonska, Sara
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
- Polish Academy of Sciences (PAN)
Research article2024Peer reviewed
Design, clinical applications and post-surgical assessment of bioresorbable 3D-printed craniofacial composite implants
Targonska, Sara; Dobrzynska-Mizera, Monika; Di Lorenzo, Maria Laura; Knitter, Monika; Longo, Alessandra; Dobrzynski, Maciej; Rutkowska, Monika; Barnas, Szczepan; Czapiga, Bogdan; Stagraczynski, Maciej; Mikulski, Michal; Muzalewska, Malgorzata; Wylezol, Marek; Rewak-Soroczynska, Justyna; Nowak, Nicole; Andrzejewski, Jacek; Reeks, John; Wiglusz, Rafal J.
Abstract
This study details the design, fabrication, clinical trials' evaluation, and analysis after the clinical application of 3D-printed bone reconstruction implants made of nHAp@PLDLLA [nanohydroxyapatite@poly(l-lactide-co-d,l-lactide)] biomaterial. The 3D-printed formulations have been tested as bone reconstruction Cranioimplants in 3 different medical cases, including frontal lobe, mandibular bone, and cleft palate reconstructions. Replacing one of the implants after 6 months provided a unique opportunity to evaluate the post-surgical implant obtained from a human patient. This allowed us to quantify physicochemical changes and develop a spatial map of osseointegration and material degradation kinetics as a function of specific locations. To the best of our knowledge, hydrolytic degradation and variability in the physicochemical and mechanical properties of the biomimetic, 3D-printed implants have not been quantified in the literature after permanent placement in the human body. Such analysis has revealed the constantly changing properties of the implant, which should be considered to optimize the design of patient-specific bone substitutes. Moreover, it has been proven that the obtained composition can produce biomimetic, bioresorbable and bone-forming alloplastic substitutes tailored to each patient, allowing for shorter surgery times and faster patient recovery than currently available methods.This paper describes in detail the design, fabrication, clinical trial evaluation and post clinical application analysis of 3D-printed bone implants made from the nHAp@PLDLLA [nanohydroxyapatite; poly(l-lactide-co-d,l-lactide)] biomaterial.
Published in
Biomaterials Science
2024, volume: 12, number: 13, pages: 3374-3388
Publisher: ROYAL SOC CHEMISTRY
SLU Authors
UKÄ Subject classification
Biomaterials Science
Publication identifier
- DOI: https://doi.org/10.1039/d3bm01826a
Permanent link to this page (URI)
https://res.slu.se/id/publ/130203