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Research article2024Peer reviewedOpen access

Molecular Mechanisms in Metal Oxide Nanoparticle−Tryptophan Interactions

Nefedova, Alexandra; Svensson, Fredric G.; Vanetsev, Alexander S.; et al.

Abstract

One of the crucial metabolic processes for both plant and animal kingdoms is the oxidation of the amino acid tryptophan (TRP) that regulates plant growth and controls hunger and sleeping patterns in animals. Here, we report revolutionary insights into how this process can be crucially affected by interactions with metal oxide nanoparticles (NPs), creating a toolbox for a plethora of important biomedical and agricultural applications. Molecular mechanisms in TRP–NP interactions were revealed by NMR and optical spectroscopy for ceria and titania and by X-ray single-crystal study and a computational study of model TRP–polyoxometalate complexes, which permitted the visualization of the oxidation mechanism at an atomic level. Nanozyme activity, involving concerted proton and electron transfer to the NP surface for oxides with a high oxidative potential, like CeO2 or WO3, converted TRP in the first step into a tricyclic organic acid belonging to the family of natural plant hormones, auxins. TiO2, a much poorer oxidant, was strongly binding TRP without concurrent oxidation in the dark but oxidized it nonspecifically via the release of reactive oxygen species (ROS) in daylight.

Keywords

Monomers; Oxidation; Oxides; Peptides and proteins; Reaction mechanisms

Published in

Inorganic Chemistry
2024, volume: 63, number: 19, pages: 8556-8566

SLU Authors

UKÄ Subject classification

Inorganic Chemistry

Publication identifier

  • DOI: https://doi.org/10.1021/acs.inorgchem.3c03674

Permanent link to this page (URI)

https://res.slu.se/id/publ/139774