Sow vaccination with a novel recombinant protein vaccine protects piglets against Streptococcus suis infection

Abstract

Streptococcus suis is a severe zoonotic pathogen affecting weaned piglets. No commercial vaccine that provides protection against S. suis is available. A prototype vaccine, tentatively called VASIP (Vaccine Against Streptococcus suis Infection in Pigs), composed of five recombinant fusion proteins, encompassing 23 different protein domains, was used in this study. Pregnant sows were vaccinated on three occasions, at 68, 47 and 19 days prior to farrowing, resulting in high antibody levels, both in sera and in colostrum. Antibodies were transferred to the litter via colostrum. The litters from VASIP-vaccinated and placebo-vaccinated sows were challenged intravenously with S. suis at four or seven weeks of age in two different arms of the study. Body temperature and clinical signs (demeanour, behavioural CNS, and mobility) of infection showed that piglets from vaccinated sows were significantly protected against S. suis infection in the 4-week-old group and that the incidence of severe clinical signs was lower in the 7-week-old group compared with piglets from placebo sows. The study demonstrates the feasibility of vaccinating sows, rather than piglets, using recombinant fusion proteins to maximise protection against S. suis during the period in which they are most at risk of disease.

Keywords

Vaccination; streptococcus suis; Colostrum; Piglet; Recombinant; Immune response; Antibodies

Published in

Vaccine
2025, volume: 53, article number: 127077

SLU Authors

• Frosth, Sara

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Bjerketorp, Joakim

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Jacobsson, Karin

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Jacobson, Magdalena

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Guss, Bengt

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Frykberg, Lars

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Clinical Science

Publication identifier

• DOI: https://doi.org/10.1016/j.vaccine.2025.127077

Permanent link to this page (URI)

https://res.slu.se/id/publ/141488