Ilchenko, Oleksandr
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
- Umeå University
Abstract
Salinomycin (SAL), originally identified for its potent antibacterial properties, has recently garnered attention for its remarkable activity against a variety of cancer types. Beyond its direct cytotoxic effects on cancer cells, SAL can also enhance the efficacy of anti-CD20 immunotherapy in B-cell malignancies, both in vitro and in vivo. Despite these promising findings, the precise molecular mechanisms underlying SAL's anticancer action remain poorly understood. Here, we demonstrate that even at low concentrations (0.25-0.5 mM), SAL disrupts mitochondrial membrane potential and induces oxidative stress in Burkitt lymphoma. Further investigations uncovered that SAL shifts cellular metabolism from mitochondrial respiration to aerobic glycolysis. Additionally, metabolomic profiling identified SAL-induced arginine depletion as a key metabolic alteration. These findings provide new insights into SAL's multifaceted mechanisms of action and support its potential as an adjunctive therapy in cancer treatment.
Keywords
salinomycin; mitochondria; mitochondrial respiration; oxidative stress; metabolomics
Published in
International Journal of Molecular Sciences
2025, volume: 26, number: 11, article number: 5125
Publisher: MDPI
SLU Authors
UKÄ Subject classification
Cell and Molecular Biology
Publication identifier
- DOI: https://doi.org/10.3390/ijms26115125
Permanent link to this page (URI)
https://res.slu.se/id/publ/142559