Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs

Abstract

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development

Published in

Nature Genetics
2007, volume: 39, number: 11, pages: 1318-1320
Publisher: NATURE PUBLISHING GROUP

SLU Authors

• Salmon Hillbertz, Nicolette

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Rönnberg, Henrik

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Gustafson, Ulla

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Hedhammar, Åke

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Andersson, Göran

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Hellmén, Eva

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Veterinary Science
Animal and Dairy Science

Publication identifier

• DOI: https://doi.org/10.1038/ng.2007.4

Permanent link to this page (URI)

https://res.slu.se/id/publ/16369