Efficient mapping of mendelian traits in dogs through genome-wide association

Abstract

With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with similar to 27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only similar to 20 dogs. Specifically, we map two traits with mendelian inheritance: the major white spotting ( S) locus and the hair ridge in Rhodesian ridgebacks. For both traits, we map the loci to discrete regions of

Published in

Nature Genetics
2007, volume: 39, number: 11, pages: 1321-1328
Publisher: NATURE PUBLISHING GROUP

SLU Authors

• Baranowska Körberg, Izabella

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Salmon Hillbertz, Nicolette

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Rönnberg, Henrik

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Hedhammar, Åke

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Andersson, Göran

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Andersson, Leif

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Veterinary Science
Animal and Dairy Science

Publication identifier

• DOI: https://doi.org/10.1038/ng.2007.10

Permanent link to this page (URI)

https://res.slu.se/id/publ/16370