Andersson, Rolf
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
Abstract
Many sessile suspension-feeding marine organisms rely on chemical defense to keep their surfaces free from fouling organisms. The brominated cyclopeptides barettin (cyclo[(6-bromo-8-entryptophan)arginine]) (1) and 8,9-dihydrobarettin (cyclo[(6-bromotryptophan)arginine]) (2) from the cold-water sponge Geodia barretti have previously displayed settlement inhibition of barnacle larvae in a dose-dependent manner. In this paper, we describe a novel dibrominated cyclopeptide, bromobenzisoxazolone barettin (cyclo[(6-bromo-8-(6-bromobenzioxazol-3(1H)-one)-8-hydroxy)tryptophan)]arginine) (3), which we have isolated from G. barretti and which displays settlement inhibition of barnacle larvae (Balanus improvisus) with an EC(50) value of 15 nM. The chemical structure was determined using MS and 2D-NMR.
Published in
Journal of Natural Products
2008, volume: 71, number: 3, pages: 330-333
Publisher: AMER CHEMICAL SOC
SLU Authors
UKÄ Subject classification
Environmental Sciences and Nature Conservation
Publication identifier
- DOI: https://doi.org/10.1021/np0705209
Permanent link to this page (URI)
https://res.slu.se/id/publ/17943