Åbrink, Magnus
- Uppsala University
Abstract
Storage and release of proteins from granules forms the basis of cellular functions as diverse as cell mediated cytotoxicity, neuronal communication, activation of muscle fibres, and release of hormones or digestive enzymes from endocrine and exocrine glands, such as the pancreas. Serglycin is the major intracellular proteoglycan of haematopoietic cells. Serglycin is important for localization of proteins in granules of different haematopoietic cell types. Previous reports have indicated a role for serglycin in granule formation and localization of zymogens in granules of the exocrine pancreas in rat. We here present data showing that serglycin is not present at the protein level in human or murine pancreas. Furthermore, the amount and localization of three exocrine pancreas zymogens (amylase, trypsinogen, and carboxypeptidase A) is not affected by the absence of serglycin in a serglycin knock-out mouse model. (C) 2009 Elsevier GmbH. All rights reserved.
Keywords
Human; Mouse; Granule formation; Secretory granules; Glycosaminoglycan; Proteoglycan; Serglycin; Sorting; Pancreas
Published in
European Journal of Cell Biology
2009, volume: 88, number: 8, pages: 473-479
SLU Authors
Pejler, Gunnar
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Cell Biology
Publication identifier
- DOI: https://doi.org/10.1016/j.ejcb.2009.03.002
Permanent link to this page (URI)
https://res.slu.se/id/publ/28023