Bovine respiratory syncytial virus ISCOMs - protection in the presence of maternal antibodies

Abstract

The protection induced by immunostimulating complexes (ISCOMs) against bovine respiratory syncytial virus (BRSV) was evaluated and compared to that of a commercial inactivated vaccine (CV) in calves with BRSV-specific maternal antibodies. Following experimental challenge, controls (n = 4) and animals immunized with CV (n = 5) developed moderate to severe respiratory disease, whereas calves immunized with ISCOMS (17 = 5) remained clinically healthy. BRSV was re-isolated from the nasopharynx of all controls and from all calves immunized with CV, but from none of the calves immunized with ISCOMs. BRSV-RNA was detected by real-time PCR from a single animal in this group. Significantly higher BRSV-specific nasal IgG, serum IgG(1) and IgG(2) titers were detected before and after challenge in animals immunized with ISCOMs versus CV. In conclusion, the ISCOMs overcame the suppressive effect of maternal antibodies in calves and induced strong clinical and virological protection against a BRSV challenge. (C) 2004 Elsevier Ltd. All rights reserved

Published in

Vaccine
2004, volume: 23, number: 5, pages: 646-655
Publisher: ELSEVIER SCI LTD

SLU Authors

• Hägglund, Sara

  • Department of Molecular Biosciences, Swedish University of Agricultural Sciences
    

• Valarcher, Jean-Francois

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Belak, Sandor

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Alenius, Stefan

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

Publication identifier

• DOI: https://doi.org/10.1016/j.vaccine.2004.07.006

Permanent link to this page (URI)

https://res.slu.se/id/publ/3857