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Sammanfattning

Hens were given single intravenous or oral doses (30 mg/kg body weight) of metronidazole and the plasma concentrations of the drug were determined by high-performance liquid chromatography (HPLC) at intervals from 10 min to 24 h after drug administration. Pharmacokinetic variables were calculated by the Lagrange algorithm technique. The elimination half-life (t(1/2 beta)) after the intravenous injection was 4.2 +/- 0.5 h, the volume of distribution (V-d(ss)) 1.1 +/- 0.2 L/hg and the total body clearance (Cl-beta) 131.2 +/- 20 mL/h . kg. Oral bioavailability of the metronidazole was 78 +/- 16%, The plasma maximum concentration (C-max) 31.9 +/- 2.3 mu g/mL was reached 2 h after the oral administration and the oral elimination half-life (t(1/2 beta)) was 4.7 +/- 0.2 h, The binding of metronidazole to proteins in hen plasma was very low (less than 3%). Whole body autoradiography of [H-3] metronidazole in hens and quails showed an even distribution of labelled material in various tissues at short survival intervals (1 - 4 h) after oral or intravenous administration. A high labelling was seen in the contents of the small and large intestines. In the laying quails a labelling was also seen in the albumen and in a ring in the periphery of the yolk at long survival intervals. Our results show that a concentration twofold above the MIC is maintained in the plasma of hens for at least 12 h at an oral dose of 30 mg/kg metronidazole.

Publicerad i

Journal of Veterinary Pharmacology and Therapeutics
1996, volym: 19, nummer: 5, sidor: 352-358
Utgivare: BLACKWELL SCIENCE LTD

SLU författare

  • Larsson, Pia

    • Institutionen för farmakologi och toxikologi, Sveriges lantbruksuniversitet

  • Tjälve, Hans

    • Institutionen för farmakologi och toxikologi, Sveriges lantbruksuniversitet

UKÄ forskningsämne

Patobiologi

Publikationens identifierare

  • DOI: https://doi.org/10.1111/j.1365-2885.1996.tb00063.x

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/40225