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Abstract

The lymphoid enhancer-binding factor-1 (LEF1) belongs to a family of regulatory proteins that share homology with the high mobility group protein-1 (HMG1). The LEF1 gene is a mediator in the canonical Wnt-signalling pathway required for morphogenesis of early mammary gland during embryogenesis. Here we describe the molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations. The 2357-bp cDNA sequence contains an 1197-bp open reading frame encoding a protein of 398 amino acids. The porcine LEF1 protein shares high identity with LEF1 in other mammalian species. The LEF1 gene contains 12 exons and maps to pig chromosome 8 (SSC8). We identified two single nucleotide polymorphisms (SNPs), a T1351C transition and an A1666C transversion, in the 3' end of LEF1. Associations of the SNP A1666C with presence of inverted teats (P

Published in

Cytogenetic and Genome Research
2009, volume: 124, number: 2, pages: 139-146
Publisher: KARGER

SLU Authors

  • Jonas, Elisabeth

    • University of Bonn

UKÄ Subject classification

Animal and Dairy Science

Publication identifier

  • DOI: https://doi.org/10.1159/000207521

Permanent link to this page (URI)

https://res.slu.se/id/publ/42072