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Research article2012Peer reviewed

Kinetics of single and dual infection of calves with an Asian atypical bovine pestivirus and a highly virulent strain of bovine viral diarrhoea virus 1

Larska, M; Polak, MP; Riitho, V; Strong, R; Belak, S; Alenius, S; Uttenthal, A; Liu, LH

Abstract

Atypical bovine pestiviruses related to bovine viral diarrhoea virus (BVDV) have recently been detected in cattle from South America, Asia and Europe. The purpose of this study was to compare the clinical and virological aspects of dual infection with BVDV-1 (Horton 916) and an Asian atypical bovine pestivirus (Th/04_KhonKaen) in naive calves, in comparison to single infections. Milder clinical signs were observed in the animals infected with single Th/04_KhonKaen strain. Leukocytopenia and lymphocytopenia were observed in all infected groups at a similar level which correlated with the onset of viraemia. Co-infection with both viruses led to prolonged fever in comparison to single strain inoculated groups and simultaneous replication of concurrent viruses in blood and in the upper respiratory tract. Following the infections all the calves seroconverted against homologous strains. Atypical pestiviruses pose a serious threat to livestock health and BVDV eradication, since they may have the potential to be widely spread in cattle populations without being detected and differentiated from other BVDV infections. (c) 2012 Elsevier Ltd. All rights reserved.

Keywords

Atypical bovine pestivirus; BVDV; Dual infection; Diagnosis; Experimental inoculation; Viraemia; Seroconversion

Published in

Comparative Immunology, Microbiology and Infectious Diseases
2012, volume: 35, number: 4, pages: 381-390

SLU Authors

UKÄ Subject classification

Clinical Science

Publication identifier

  • DOI: https://doi.org/10.1016/j.cimid.2012.03.003

Permanent link to this page (URI)

https://res.slu.se/id/publ/43300