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Abstract

Zebrafish (Danio rerio) were orally exposed to a mixture of 20 PCBs in three different dose levels (0.008, 0.08, and 0.4 mu g of each congener per gram of freeze-dried chironomids). Generally, the PCBs accumulated in a dose-related manner. After 13 weeks of exposure body, liver, and ovary weights, as well as the liver and ovary somatic index, were significantly lower in exposed groups. In addition, the PCB mixture was an effective inducer of hepatic EROD activity. The reproduction study performed with exposed females and unexposed males after 9 weeks revealed that median survival time for larvae was only 7.7 days in the high-dose group as compared with 14 days in controls. Furthermore, egg production was reduced in all three groups exposed. No differences in hatching frequency or median hatching time were recorded. Histologically, females in both the intermediate and high-dose groups contained a reduced number of mature oocytes, The present study demonstrates that the potency of the mixture of selected PCBs induces hepatic EROD activity and has a clearly negative effect on zebrafish reproduction.

Keywords

RAINBOW-TROUT; BRACHYDANIO-RERIO; CHLORINATED HYDROCARBONS; GASTEROSTEUS-ACULEATUS; 3-SPINED STICKLEBACK; ONCORHYNCHUS-MYKISS; HATCHING SUCCESS; ATLANTIC CROAKER; AROCLOR 1254; CLOPHEN-A50

Published in

Archives of Environmental Contamination and Toxicology
1998, volume: 35, number: 1, pages: 52-57
Publisher: SPRINGER VERLAG

SLU Authors

UKÄ Subject classification

Environmental Sciences

Publication identifier

  • DOI: https://doi.org/10.1007/s002449900348

Permanent link to this page (URI)

https://res.slu.se/id/publ/43524