Hillström, Anna
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Abstract
Hereditary phosphofructokinase (PFK) deficiency was diagnosed in two Wachtelhund dogs and suspected in three related Wachtelhund dogs with exercise intolerance, hemolytic anemia, and pigmenturia. Severe, persistent reticulocytosis in light of only mild anemia together with hemoglobinuria after strenuous exercise suggested PFK deficiency. Low erythrocyte PFK activity together with low 2,3-diphosphoglycerate concentrations and a high hemoglobin-oxygen affinity confirmed the diagnosis. The PFK deficiency is due to a single missense mutation in the muscle-type PFK M-PFK gene in English springer and American cocker spaniels, whippets, and mixed-breed dogs; however, these PFK-deficient Wachtelhunds do not have the same PFK mutation.
Published in
Journal Of The American Animal Hospital Association
2011, volume: 47, number: 2, pages: 145-150
Publisher: AMER ANIMAL HOSPITAL ASSOC
SLU Authors
Tvedten, Harold
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Veterinary Science
Animal and Dairy Science
Publication identifier
- DOI: https://doi.org/10.5326/JAAHA-MS-5619
Permanent link to this page (URI)
https://res.slu.se/id/publ/47183