Genetic Variants and Disease-Associated Factors Contribute to Enhanced Interferon Regulatory Factor 5 Expression in Blood Cells of Patients With Systemic Lupus Erythematosus

Feng, D; Stone, Rivka C.; Eloranta, Maija-Leena; Sangster-Guity, N; Nordmark, Gunnel; Sigurdsson, Snaevar; Wang, Chuan; Alm, Gunnar; Syvänen, Ann-Christine; Rönnblom, Lars; Barnes, Betsy J.

doi:10.1002/art.27223

Research article2010Peer reviewedOpen access

Genetic Variants and Disease-Associated Factors Contribute to Enhanced Interferon Regulatory Factor 5 Expression in Blood Cells of Patients With Systemic Lupus Erythematosus

Feng, D; Stone, Rivka C.; Eloranta, Maija-Leena; Sangster-Guity, N; Nordmark, Gunnel; Sigurdsson, Snaevar; Wang, Chuan; Alm, Gunnar; Syvänen, Ann-Christine; Rönnblom, Lars; Barnes, Betsy J.

Abstract

Conclusion. This study provides the first formal proof that IRF-5 expression and alternative splicing are significantly up- regulated in primary blood cells of patients with SLE. Furthermore, the risk haplotype is associated with enhanced IRF-5 transcript and protein expression in patients with SLE.

Published in

Arthritis and Rheumatism
2010, volume: 62, number: 2, pages: 562-573
Publisher: WILEY-BLACKWELL

SLU Authors

Eloranta, Maija-Leena
- Uppsala University
Alm, Gunnar
- Department of Animal Biosciences, Swedish University of Agricultural Sciences

UKÄ Subject classification

Clinical Medicine

Publication identifier

DOI: https://doi.org/10.1002/art.27223

Permanent link to this page (URI)

https://res.slu.se/id/publ/48073