Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients

Omri, Snir; Widhe, Mona; Hermansson, Monika; von Spee, Caroline; Lindberg, Johan; Hensen, Sanne; Lundberg, Karin; Engström, Åke; Venables, Patrick J. W.; Toes, Rene E. M.; Holmdahl, Rikard; Klareskog, L; Malmstrom, Vivianne

doi:10.1002/art.25036

Research article2010Peer reviewed

Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients

Omri, Snir; Widhe, Mona; Hermansson, Monika; von Spee, Caroline; Lindberg, Johan; Hensen, Sanne; Lundberg, Karin; Engström, Åke; Venables, Patrick J. W.; Toes, Rene E. M.; Holmdahl, Rikard; Klareskog, L; Malmstrom, Vivianne

Abstract

Conclusion. MCV and CCP positivity represent a similar subset of RA patients, whereas ACPAs with different fine specificities fall into subgroups of anti-CCP+/anti-MCV+ patients. The levels of all specific ACPAs were elevated in synovial fluid, suggesting that there is local antibody production and/or retention of ACPAs at the site of inflammation governed by RA-predisposing genes.

Published in

Arthritis and Rheumatism
2010, volume: 62, number: 1, pages: 44-52
Publisher: WILEY-LISS

SLU Authors

Widhe, Mona
- Karolinska Institute

UKÄ Subject classification

Clinical Medicine

Publication identifier

DOI: https://doi.org/10.1002/art.25036

Permanent link to this page (URI)

https://res.slu.se/id/publ/48110