Dose-response-time data analysis involving nonlinear dynamics, feedback and delay

Abstract

This paper offers dose-response-time data analysis of four different case studies where the pharmacological response (neuronal ACh-release, tail-flick response, locomotor activity, NEFA) was modelled by a biophase-driven turnover model. The analysis uses a mathematical/analytical perspective in which analytic properties of the models involved are exploited in order to address the dual challenge of extracting information from these time-series about (i) the biophase kinetics following different routes of administration and (ii) pharmacodynamic issues such as transduction, saturation, and adaptation, and more specifically, parameter identifiability, such as correct estimation of potency (SD50 or ID50). It is shown how many of these estimates can be obtained by analytical means, giving considerable insight in the dynamics involved. (C) 2014 Elsevier B.V. All rights reserved.

Keywords

Dose-response-time analysis; Turnover; Biophase; K-PD models

Published in

European Journal of Pharmaceutical Sciences
2014, volume: 59, pages: 36-48

SLU Authors

• Gabrielsson, Johan

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

Associated SLU-program

Cross-programme

UKÄ Subject classification

Physiology and Anatomy
Pharmaceutical Sciences
Pharmacology and Toxicology

Publication identifier

• DOI: https://doi.org/10.1016/j.ejps.2014.04.007

Permanent link to this page (URI)

https://res.slu.se/id/publ/66205