Galkina, Olga
- Russian Academy of Sciences
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
Abstract
Nanocomposite dermal drug delivery systems based on cellulose nanofibers with grafted titania nanoparticles loaded by two antibiotic medicines from different classes, i.e. tetracycline (TC) and phosphomycin (Phos), were successfully produced by a "green chemistry'' approach in aqueous media. The influence of a different surface binding mechanism between the drug molecule and modified cellulose nanofibers on the release of the drug and, as a result, on antimicrobial properties against common pathogens Gram-positive, Staphylococcus aureus and Gram-negative Escherichia coli was investigated. The disk diffusion method and broth culture tests using varying concentrations of drugs loaded to nanocomposites were carried out to investigate the antibacterial effects. The influence of UV irradiation on the stability of the obtained nanocomposites and their antibacterial properties after irradiation were also investigated, showing enhanced stability especially for the TC loaded materials. These findings suggest that the obtained nanocomposites are promising materials for the development of potentially useful antimicrobial patches.
Published in
Journal of Materials Chemistry B
2015, volume: 3, number: 35, pages: 7125-7134
Publisher: ROYAL SOC CHEMISTRY
SLU Authors
Önneby, Karin
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
Seisenbaeva, Gulaim
- CaptiGel AB
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
Kessler, Vadim
- CaptiGel AB
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
UKÄ Subject classification
Organic Chemistry
Materials Chemistry
Inorganic Chemistry
Publication identifier
- DOI: https://doi.org/10.1039/c5tb01382h
Permanent link to this page (URI)
https://res.slu.se/id/publ/68726