Concentrations in plasma of testosterone, estradiol and LH, and accessory sex gland weights in boars exposed to Di(2-ethylhexyl) Phthalate before puberty

Abstract

The widely used plastic softener Di(2-ethylhexyl) Phthalate (DEHP) is considered to be an endocrine disrupting chemical (EDC) in rodents. This study describes the reproductive endocrinology of the boar (n=20) from three weeks of age to seven weeks of age, and the effects of exposure to 300 mg/kg DEHP p.o.(n=20), three times weekly, during the same period. The experiments were conducted in a “split litter”-design, with two full siblings in each group. Blood samples were collected once weekly from three to seven weeks of age and analysed for testosterone, estradiol and LH. At adulthood, eight boars from each group were given an i.v. injection of a synthetic GnRH-analogue, and the concentrations of testosterone and LH were analysed. The accessory sex glands were removed at sacrifice at seven weeks and nine months of age, respectively. In the control animals there was a transient decrease (p

Conference

ESDAR

SLU Authors

• Ljungvall, Karl

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Spjuth, Linda

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Hulten, Fredrik

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Magnusson, Ulf

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Environmental Sciences and Nature Conservation

Permanent link to this page (URI)

https://res.slu.se/id/publ/7743