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Abstract

Cardiovascular disease in humans and dogs is associated with mildly increased circulating concentrations of C-reactive protein (CRP). Few studies have evaluated associations between circulating CRP and canine myxomatous mitral valve disease (MMVD) and the results reported have been divergent. The aim of this study was to investigate whether serum concentrations of CRP, determined using a novel automated canine-specific high -sensitivity CRP assay (Gentian hsCRP), were associated with severity of MMVD and selected clinical variables in dogs. The study included 188 client-owned dogs with different severities of MMVD. Dogs were classified based on ACVIM consensus statement guidelines (group A, n = 58; group BI, n = 56; group B2, n = 38; group C, n = 36). Data were analysed using descriptive statistics and multiple regression analysis.Dogs with congestive heart failure (CHF; group C) had significantly higher CRP concentrations (median, 2.65 mg/L; quartile 1 -quartile 3, 1.09-5.09) compared to dogs in groups A (median, 0.97 mg/L; quartile 1-quartile 3,

Keywords

CRP; Mitral regurgitation; Dog; Inflammation; Valvular disease

Published in

Veterinary Journal
2016, volume: 209, pages: 113-118
Publisher: ELSEVIER SCI LTD

SLU Authors

UKÄ Subject classification

Other Veterinary Science

Publication identifier

  • DOI: https://doi.org/10.1016/j.tvjl.2015.12.006

Permanent link to this page (URI)

https://res.slu.se/id/publ/79345