Karlsson Tiselius, Andreas
- Department of Molecular Biology, Swedish University of Agricultural Sciences
Abstract
Three-dimensional structures of the ethanol-induced, tetrameric alcohol dehydrogenase from Escherichia coli have recently been determined in the absence and presence of NAD. The structure of the E coli enzyme is similar to those of the dimeric mammalian alcohol dehydrogenases, but it has a deletion of 21 residues located at the surface of the catalytic domain. The catalytic zinc ions have two different types of coordination, which are also observed in the class III dimeric mammalian alcohol dehydrogenase. Comparison of the structures provide new insights into the relationship between tetrameric and dimeric alcohol dehydrogenases and provide a link to the structure of the tetrameric yeast alcohol dehydrogenase. circle dot 2002 Elsevier Science Ireland Ltd. All rights reserved
Published in
Chemico-Biological Interactions
2003, volume: 143, pages: 239-245
Publisher: ELSEVIER SCI IRELAND LTD
SLU Authors
Eklund, Hans
- Department of Molecular Biology, Swedish University of Agricultural Sciences
- Department of Molecular Biology, Swedish University of Agricultural Sciences
UKÄ Subject classification
Food Science
Bioenergy
Publication identifier
- DOI: https://doi.org/10.1016/S0009-2797(02)00222-3
Permanent link to this page (URI)
https://res.slu.se/id/publ/800