Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse

Abstract

A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (ScIC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha(2)-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG. (c) 2006 Elsevier Ltd. All rights reserved

Published in

Vaccine
2006, volume: 24, number: 19, pages: 4144-4151
Publisher: ELSEVIER SCI LTD

SLU Authors

• Lannergård, Jonas

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

• Guss, Bengt

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

Publication identifier

• DOI: https://doi.org/10.1016/j.vaccine.2006.02.016

Permanent link to this page (URI)

https://res.slu.se/id/publ/8170