Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission

Safra, Noa; Hitchens, Peta L.; Maverakis, Emanual; Mitra, Anupam; Korff, Courtney; Johnson, Eric; Kol, Amir; Bannasch, Michael J.; Pedersen, Niels C.; Bannasch, Danika L.

doi:10.1016/j.vetimm.2016.08.003

Research article2016Peer reviewedOpen access

Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission

Safra, Noa; Hitchens, Peta L.; Maverakis, Emanual; Mitra, Anupam; Korff, Courtney; Johnson, Eric; Kol, Amir; Bannasch, Michael J.; Pedersen, Niels C.; Bannasch, Danika L.

Abstract

Metaphyseal osteopathy (MO) (hypertrophic osteodystrophy) is a developmental disorder of unexplained etiology affecting dogs during rapid growth. Affected dogs experience relapsing episodes of lytic/sclerotic metaphyseal lesions and systemic inflammation. MO is rare in the general dog population; however, some breeds (Weimaraner, Great Dane and Irish Setter) have a much higher incidence, supporting a hereditary etiology. Autoinflammatory childhood disorders of parallel presentation such as chronic recurrent multi focal osteomyelitis (CRMO), and deficiency of interleukin-1 receptor antagonist (DIRA), involve impaired innate immunity pathways and aberrant cytokine production. Given the similarities between these diseases, we hypothesize that MO is an autoinflammatory disease mediated by cytokines involved in innate immunity. To characterize immune dysregulation in MO dogs we measured serum levels of inflammatory markers in 26 MO and 102 control dogs. MO dogs had significantly higher levels (pg/ml) of serum Interleukin-1beta (IL-1 beta), IL-18, IL-6, Granulocyte-macrophage colony stimulating factor (GM-CSF), C-X-C motif chemokine 10 (CXCL10), tumor necrosis factor (TNF), and IL-10. Notably, recovered MO dogs were not different from dogs during active MO disease, providing a suggestive mechanism for disease predisposition. This is the first documentation of elevated immune markers in MO dogs, uncovering an immune profile similar to comparable autoinflammatory disorders in children. (C) 2016 Elsevier B.V. All rights reserved.

Keywords

Canine; Hypertrophic osteodystrophy; Innate immunity; Autoinflammatory; Cytokines

Published in

Veterinary Immunology and Immunopathology
2016, volume: 179, pages: 32-35
Publisher: ELSEVIER SCIENCE BV

SLU Authors

Hitchens, Peta
- Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
- University of California Davis (UC Davis)

UKÄ Subject classification

Pathobiology

Publication identifier

DOI: https://doi.org/10.1016/j.vetimm.2016.08.003

Permanent link to this page (URI)

https://res.slu.se/id/publ/83249