Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

Abstract

Background: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.Objectives: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects. Methods: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter

Keywords

Long-term exposure; Particulate matter; Elemental components; Inflammation; ESCAPE; TRANSPHORM

Published in

Environment International
2015, volume: 82, pages: 76-84
Publisher: PERGAMON-ELSEVIER SCIENCE LTD

SLU Authors

• Penell, Johanna

  • Karolinska Institute

UKÄ Subject classification

Public Health, Global Health and Social Medicine
Environmental Health and Occupational Health
Epidemiology

Publication identifier

• DOI: https://doi.org/10.1016/j.envint.2015.05.008

Permanent link to this page (URI)

https://res.slu.se/id/publ/83984