Schwelm, Arne
- Massey University
Abstract
Dothistromin is a non-host selective toxin produced by the pine needle pathogen Dothistroma septosporum. Dothistromin is not required for pathogenicity, but may have a role in competition and niche protection. To determine how D. septosporum tolerates its own toxin, a putative dothistromin transporter, DotC, was investigated. Studies with mutants lacking a functional dotC gene, overproducing DotC, or with a DotC-GFP fusion gene, did not provide conclusive evidence of a role in dothistromin efflux. The mutants revealed a major effect of DotC on dothistromin biosynthesis but were resistant to exogenous dothistromin. Intracellular localization studies suggest that compartmentalization may be important for dothistromin tolerance.
Keywords
aflatoxin biosynthesis; Dothistroma septosporum; major facilitator superfamily; toxin transporter; red-band needle blight
Published in
Toxins
2009, volume: 1, number: 2, pages: 173-187
SLU Authors
UKÄ Subject classification
Forest Science
Publication identifier
- DOI: https://doi.org/10.3390/toxins1020173
Permanent link to this page (URI)
https://res.slu.se/id/publ/84707