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Abstract

In this work the syntheses, structure and SOD activity of covalently grafted Fe(III)-complexes formed with various N- or C-protected amino acid ligands (L-histidine and L-tyrosine) inspired by the active site of the Fe SOD enzyme are presented. Chloropropylated silica gel was used as support to mimic the proteomic skeleton of the enzyme. Anchored complexes having uniform amino acids as well as their two-component mixtures have been prepared. The products were characterised by mid and far IR and Raman spectroscopies. SOD activities of the substances were determined via the Beauchamp-Fridovich test reaction. It was found that the preparation of covalently anchored Fe(III)-amino acid complexes was successful in many cases. The structures of the anchored complexes and the coordinating groups varied upon changing the conditions of the syntheses. All the covalently immobilised complexes displayed (in some instances appreciable) SOD activity. (C) 2012 Elsevier B.V. All rights reserved.

Keywords

Fe(III)-amino acid complexes; Immobilisation by covalent anchoring; Structural characterisation; Superoxide dismutase activity

Published in

Journal of Molecular Structure
2013, volume: 1044, pages: 39-45
Publisher: ELSEVIER SCIENCE BV

SLU Authors

  • Bajnóczi, Eva

    • University of Szeged

UKÄ Subject classification

Inorganic Chemistry

Publication identifier

  • DOI: https://doi.org/10.1016/j.molstruc.2012.11.019

Permanent link to this page (URI)

https://res.slu.se/id/publ/85912