Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins

Abstract

Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.

Keywords

Microcystins; Oxidative stress; Nrf2

Published in

Toxicon
2017, volume: 126, pages: 47-50

SLU Authors

• Lundqvist, Johan

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Oskarsson, Agneta

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

Global goals (SDG)

SDG6 Clean water and sanitation

UKÄ Subject classification

Environmental Health and Occupational Health
Pharmacology and Toxicology

Publication identifier

• DOI: https://doi.org/10.1016/j.toxicon.2016.12.012

Permanent link to this page (URI)

https://res.slu.se/id/publ/88794