Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd-0-CalB CLEA as a Biohybrid Catalyst

Gustafson, Karl P. J.; Gorbe, Tamas; de Gonzalo-Calvo, Gonzalo; Yuan, Ning; Schreiber, Cynthia L.; Shchukarev, Andrey; Tai, Cheuk-Wai; Persson, Ingmar; Zou, Xiaodong; Backvall, Jan-E.

doi:10.1002/chem.201901418

Research article2019Peer reviewedOpen access

Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd-0-CalB CLEA as a Biohybrid Catalyst

Gustafson, Karl P. J.; Gorbe, Tamas; de Gonzalo-Calvo, Gonzalo; Yuan, Ning; Schreiber, Cynthia L.; Shchukarev, Andrey; Tai, Cheuk-Wai; Persson, Ingmar; Zou, Xiaodong; Backvall, Jan-E.

Abstract

Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.

Keywords

amides; biohybrid catalysts; dynamic kinetic resolution; heterogeneous catalysis; key cross-linked enzyme aggregates

Published in

Chemistry - A European Journal
2019, volume: 25, number: 39, pages: 9174-9179
Publisher: WILEY-V C H VERLAG GMBH

SLU Authors

Yuan, Ning
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
- Stockholm University
Persson, Ingmar
- Department of Molecular Sciences, Swedish University of Agricultural Sciences

UKÄ Subject classification

Organic Chemistry

Publication identifier

DOI: https://doi.org/10.1002/chem.201901418

Permanent link to this page (URI)

https://res.slu.se/id/publ/101218