Skip to main content
Review article - Peer-reviewed, 2019

African Swine Fever: Disease Dynamics in Wild Boar Experimentally Infected with ASFV Isolates Belonging to Genotype I and II

Sanchez-Cordon, Pedro J.; Nunez, Alejandro; Neimanis, Aleksija; Wikstrom-Lassa, Emil; Montoya, Maria; Crooke, Helen; Gavier-Widen, Dolores


After the re-introduction of African swine fever virus (ASFV) genotype II isolates into Georgia in 2007, the disease spread from Eastern to Western Europe and then jumped first up to Mongolian borders and later into China in August 2018, spreading out of control and reaching different countries of Southeast Asia in 2019. From the initial incursion, along with domestic pigs, wild boar displayed a high susceptibility to ASFV and disease development. The disease established self-sustaining cycles within the wild boar population, a key fact that helped its spread and that pointed to the wild boar population as a substantial reservoir in Europe and probably also in Asia, which may hinder eradication and serve as the source for further geographic expansion. The present review gathers the most relevant information available regarding infection dynamics, disease pathogenesis and immune response that experimental infections with different ASFV isolates belonging to genotype I and II in wild boar and feral pigs have generated. Knowledge gaps in areas such as disease pathogenesis and immune response highlights the importance of focusing future studies on unravelling the early mechanisms of virus-cell interaction and innate and/or adaptive immune responses, knowledge that will contribute to the development of efficacious treatments/vaccines against ASFV.


African swine fever virus; genotype I and II; wild boar; experimental infection

Published in

2019, volume: 11, number: 9, article number: 852
Publisher: MDPI

Authors' information

Sanchez-Cordon, Pedro J.
APHA Weybridge
Nunez, Alejandro
APHA Weybridge
Neimanis, Aleksija
Natl Vet Inst SVA
Wikstrom-Lassa, Emil
Natl Vet Inst SVA
Montoya, Maria
Consejo Superior de Investigaciones Cientificas (CSIC)
Crooke, Helen
APHA Weybridge
Gavier-Widen, Dolores (Gavier Widén, Dolores)
National Veterinary Institute (SVA)
Gavier-Widen, Dolores (Gavier Widén, Dolores)
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health

Sustainable Development Goals

SDG3 Good health and well-being

UKÄ Subject classification


Publication Identifiers


URI (permanent link to this page)