Abstract

Harmonized embryo maternal relationships, are necessary at the beginning of pregnancy to insure the development of the young embryo and of the placenta. Specific mechanisms modulate the immune balance towards immune-tolerance for the embryo to be accepted by the endometrium. By the same time this tissue is submitted to intense remodelling, under complex signalling, allowing implantation. Some pathogens and metabolic stress, especially excessive mobilisation of fat tissue, disturb this delicate balance. This review describes how these stressors can alter endometrial function through pro-inflammatory mechanisms and by inducing changes of specific signals possibly altering the establishment of contacts and functional interactions between the embryo and the endometrium around time of implantation.

Published in

Revista Brasileira de Reprodução Animal
2019, Volume: 43, number: 2, pages: 295-307

Conference

XXIII Congresso Brasileiro de Reprodução Animal (CBRA-2019), 2019-05-15--2019-05-19, Gramado, Brazil

SLU Authors

• Guo, Yongzhi

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Chankeaw, Wiruntita

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    
  • Rajamangala University of Technology

• Valarcher, Jean-Francois

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Båge, Renee

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Bongcam Rudloff, Erik

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Andersson, Göran

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Humblot, Patrice

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Clinical Science


Permanent link to this page (URI)

https://res.slu.se/id/publ/103455