Research article - Peer-reviewed, 2019
Zebrafish (Danio rerio) embryo-larvae locomotor activity data analysis: Evaluating anxiolytic effects of the antidepressant compound citalopram
Pohl, JohannesAbstract
Newly fertilized zebrafish (Danio rerio) embryos were exposed to increasing concentrations of the selective serotonin reuptake inhibitor (SSRI) citalopram from fertilization until six days post-fertilization (dpf). Locomotor activity data were acquired at six dpf using an automated ZebraBox (R) infrared tracking system. Individual (n = 32) locomotor activity was recorded during 75 minutes in total during alternating illumination conditions (0% light, i.e. dark periods, and 100% light, i.e. light periods). The first 15 minutes of the test consisted of a dark period, i.e an acclimatization phase. Afterward, six alternating light and dark periods were conducted. Individual zebrafish embryo-larvae locomotion was tracked and aggregated in ten-second bins. The dataset, containing nine locomotor-related quantified endpoints (factors), was parsed, analyzed, and visualized using R software. The dataset and its associated custom R script may be used to further explore locomotor activity outcomes (e.g. anxiolytic or anxiogenic properties) following exposure to citalopram or other neuroactive chemicals. (c) 2019 The Author(s). Published by Elsevier Inc.Keywords
Zebrafish; Behavior; Locomotor activity; Developmental biology; Developmental neurotoxicologyPublished in
Data in Brief2019, volume: 27, article number: 104812
Authors' information
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
UKÄ Subject classification
Behavioral Sciences Biology
Developmental Biology
Publication Identifiers
DOI: https://doi.org/10.1016/j.dib.2019.104812
URI (permanent link to this page)
https://res.slu.se/id/publ/104377