Epistasis and the release of genetic variation during long-term selection

Abstract

It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model

Published in

Nature Genetics
2006, Volume: 38, number: 4, pages: 418-420 Publisher: NATURE PUBLISHING GROUP

SLU Authors

• Strömstedt, Lina

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Andersson, Leif

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Carlborg, Örjan

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science


Publication identifier

DOI: https://doi.org/10.1038/ng1761

Permanent link to this page (URI)

https://res.slu.se/id/publ/10481