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Research article2020Peer reviewedOpen access

Genome constellations of rotavirus a isolated from avian species in Brazil, 2008-2015

Beserra, Laila A. R.; Barbosa, Carla M.; Berg, Mikael; Brandao, Paulo E.; Soares, Rodrigo M.; Gregori, Fabio


Rotaviruses are members of the family Reoviridae and are a common cause of acute diarrhea in many mammalian and avian species. They are non-enveloped icosahedral particles and their genome comprises 11 segments of double-stranded RNA, which encodes six structural proteins (VP1-4, VP6-7) and six nonstructural proteins (NSP1-6). Genotypes are defined based upon the diversity found in these genes and viral characterization plays a central role on epidemiological studies and prevention. Here we investigate the distribution of Brazilian RVAs genotypes in 8 chicken samples collected between 2008 and 2015 from different regions by RT-PCR, partial (Sanger) nucleotide sequencing and phylogenetic analysis from all rotavirus genes. Although the identified genotypes were typical from avian host species, when analyzed together, they form novel genetic constellations: G19-P[31]-I11-R6-C6-M7-A16-N6-T8-E10-H8 and G19-P[31]-I4-R4-C4-M4-A16-N4-T4-E4-H4. This study highlights that avian rotaviruses are widespread among commercial farms in Brazil, and the co-circulation of at least two different genomic constellations indicates that may present a way bigger genetic variability, that can be increased by the possible transmission events from other birds, lack of specific preventive measures, as well as the different viral evolution mechanisms.


Rotavirus; Avian; Diversity; Genotypes; Sequence analysis; Phylogeny

Published in

Brazilian Journal of Microbiology
2020, Volume: 51, number: 3, pages: 1363-1375
Publisher: SPRINGER

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    Correction in: Brazilian Journal of Microbiology, 2020, DOI: 10.1007/s42770-020-00407-w

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