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Research article1992Peer reviewed

Interactions between Immune‐Stimulating Complexes (ISCOMs) and Peritoneal Mononuclear Leucocytes

WATSON, DL; WATSON, NA; FOSSUM, C; LOVGREN, K; MOREIN, B

Abstract

Studies were undertaken in mice using immune-stimulating complexes (ISCOMs) or micelles prepared from envelope glycoproteins of human influenza virus (PR8) and matrix (i.e., ISCOM skeleton without incorporated antigen). Electron microscopic studies showed that ISCOMs, in contrast to micelles, have a remarkable affinity for cell membranes and seem to rapidly promote their own internalization by cells to which they adhere. PR8 ISCOMs, but not matrix nor micelles, significantly increased the expression of membrane Ia by peritoneal mononuclear leucocytes 24 hr after intraperitoneal immunization.

Published in

Microbiology and Immunology
1992, Volume: 36, number: 2, pages: 199-203
Publisher: CENTER ACADEMIC PUBL JAPAN

      SLU Authors

    • Fossum, Caroline

      • Department of Veterinary Microbiology, Swedish University of Agricultural Sciences

      • Morein, Bror

        • Department of Veterinary Microbiology, Swedish University of Agricultural Sciences

      UKÄ Subject classification

      Microbiology

      Publication identifier

      DOI: https://doi.org/10.1111/j.1348-0421.1992.tb01657.x

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/106599