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Review article - Peer-reviewed, 2020

Do Mast Cells Have a Role in Tendon Healing and Inflammation?

Alim, Md Abdul; Peterson, Magnus; Pejler, Gunnar


Understanding the links between the tendon healing process, inflammatory mechanisms, and tendon homeostasis/pain after tissue damage is crucial in developing novel therapeutics for human tendon disorders. The inflammatory mechanisms that are operative in response to tendon injury are not fully understood, but it has been suggested that inflammation occurring in response to nerve signaling, i.e., neurogenic inflammation, has a pathogenic role. The mechanisms driving such neurogenic inflammation are presently not clear. However, it has recently been demonstrated that mast cells present within the injured tendon can express glutamate receptors, raising the possibility that mast cells may be sensitive to glutamate signaling and thereby modulate neurogenic inflammation following tissue injury. In this review, we discuss the role of mast cells in the communication with peripheral nerves, and their emerging role in tendon healing and inflammation after injury.


tendon healing; mast cells; neuropeptides; inflammation; tendon pain

Published in

2020, volume: 9, number: 5
Publisher: MDPI

Authors' information

Alim, Md Abdul
Uppsala Univ
Peterson, Magnus
Uppsala Univ
Uppsala University
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)

UKÄ Subject classification

Cell Biology

Publication Identifiers


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