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Review article - Peer-reviewed, 2020

Sperm DNA Integrity and Male Fertility in Farm Animals: A Review

Kumaresan, Arumugam; Das Gupta, Mohua; Datta, Tirtha Kumar; Morrell, Jane M.

Abstract

The accurate prediction of male fertility is of major economic importance in the animal breeding industry. However, the results of conventional semen analysis do not always correlate with field fertility outcomes. There is evidence to indicate that mammalian fertilization and subsequent embryo development depend, in part, on the inherent integrity of the sperm DNA. Understanding the complex packaging of mammalian sperm chromatin and assessment of DNA integrity could potentially provide a benchmark in clinical infertility. In the era of assisted reproduction, especially whenin-vitrofertilization or gamete intrafallopian transfer or intracytoplasmic sperm injection is used, assessment of sperm DNA integrity is important because spermatozoa are not subjected to the selection process occurring naturally in the female reproductive tract. Although sperm DNA integrity testing measures a significant biological parameter, its precise role in the infertility evaluation in farm animals remains unclear. In this review, the earlier findings on sperm DNA integrity in relation to male fertility are compiled and analyzed. Furthermore, the causes and consequences of sperm DNA damage are described, together with a review of advances in methods for detection of sperm DNA damage, and the prognostic value of sperm DNA quality on male fertility.

Keywords

male infertility; sperm; DNA integrity; epigenetic modifications; prognostic value

Published in

Frontiers in Veterinary Science
2020, volume: 7, article number: 321

Authors' information

Kumaresan, Arumugam
Natl Dairy Res Inst ICAR
Das Gupta, Mohua
Natl Dairy Res Inst ICAR
Datta, Tirtha Kumar
Natl Dairy Res Inst ICAR
Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Clinical Science
Animal and Dairy Science

Publication Identifiers

DOI: https://doi.org/10.3389/fvets.2020.00321

URI (permanent link to this page)

https://res.slu.se/id/publ/107173