Research article - Peer-reviewed, 2020
The chromogranin A-derived peptides catestatin and vasostatin in dogs with myxomatous mitral valve disease
Hoglund, Katja; Haggstrom, Jens; Hoglund, Odd Viking; Stridsberg, Mats; Tidholm, Anna; Ljungvall, IngridAbstract
Background The protein chromogranin A (CgA) is stored and co-released with catecholamines from the stimulated adrenal glands. Increased plasma concentrations of CgA have been shown in people with heart disease. The aim of the study was to investigate whether plasma concentrations of the CgA-derived biologically active peptides catestatin and vasostatin were associated with the severity of myxomatous mitral valve disease (MMVD) in dogs and to assess potential associations between these blood variables and dog characteristics, echocardiographic variables, heart rate (HR), blood pressure (BP) and plasma N-terminal-proBNP (NT-proBNP) concentration. Sixty-seven privately owned dogs with or without MMVD were included. The dogs underwent physical examination, blood pressure measurement, blood sample collection, and echocardiographic examination. Plasma concentrations of catestatin and vasostatin were analyzed using radioimmunoassay. Results Catestatin concentration decreased with increasing left atrial and ventricular size (R-2 <= 0.09, P <= 0.019), and increased with increasing systolic and diastolic blood pressures (R-2 <= 0.08, P <= 0.038). Regression analyses showed no significant associations for vasostatin. No differences in plasma concentrations of catestatin or vasostatin were found between the disease severity groups used in the study. Conclusions In the present dog population, the catestatin concentration showed weak negative associations with left atrial and ventricular sizes, both of which are known to increase with increasing severity of MMVD. Furthermore, the catestatin concentration showed weak positive associations with blood pressure.Keywords
Canine; Catestatin; Heart; Sympathetic nervous system; VasostatinPublished in
Acta Veterinaria Scandinavica2020, volume: 62, number: 1, article number: 43
Publisher: BMC
Authors' information
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Stridsberg, Mats
Uppsala University
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, Department of Clinical Sciences
UKÄ Subject classification
Clinical Science
Publication Identifiers
DOI: https://doi.org/10.1186/s13028-020-00541-3
URI (permanent link to this page)
https://res.slu.se/id/publ/107749