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Review article - Peer-reviewed, 2020

Immunoglobulins as Biomarkers for Gastrointestinal Nematodes Resistance in Small Ruminants: A systematic review

Aboshady, H. M.; Stear, M. J.; Johansson, A.; Jonas, E.; Bambou, J. C.

Abstract

The rise of anthelmintic resistance worldwide has led to the development of alternative control strategies for gastrointestinal nematodes (GIN) infections, which are one of the main constraints on the health of grazing small ruminants. Presently, breeding schemes rely mainly on fecal egg count (FEC) measurements on infected animals which are time-consuming and requires expertise in parasitology. Identifying and understanding the role of immunoglobulins in the mechanisms of resistance could provide a more efficient and sustainable method of identifying nematode-resistant animals for selection. In this study we review the findings on immunoglobulin response to GIN in the literature published to date (june 2019) and discuss the potential to use immunoglobulins as biomarkers. The literature review revealed 41 studies which measured at least one immunoglobulin: 35 focused on lamb immune response (18 used non-naive lambs) and 7 on yearlings. In this review we propose a conceptual model summarizing the role of immunoglobulins in resistance to GIN. We highlight the need for more carefully designed and documented studies to allow comparisons across different populations on the immunoglobulin response to GIN infection.

Published in

Scientific Reports
2020, volume: 10, number: 1, article number: 7765
Publisher: NATURE PUBLISHING GROUP

Authors' information

Aboshady, Hadeer M. (Aboshady, Hadeer M.)
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Aboshady, Hadeer M. (Aboshady, Hadeer M.)
AgroParisTech
Aboshady, Hadeer M. (Aboshady, Hadeer M.)
National Institute of Agricultural Research (INRA)
Aboshady, Hadeer M. (Aboshady, Hadeer M.)
Cairo University
Stear, M. J.
La Trobe University
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Jonas, Elisabeth
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Bambou, J. C.
INRAE

Associated SLU-program

SLUsystematic

UKÄ Subject classification

Animal and Dairy Science

Publication Identifiers

DOI: https://doi.org/10.1038/s41598-020-64775-x

URI (permanent link to this page)

https://res.slu.se/id/publ/107795