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Research article - Peer-reviewed, 2020

Chlamydial contribution to anaerobic metabolism during eukaryotic evolution

Stairs, Courtney W.; Dharamshi, Jennah E.; Tamarit, Daniel; Eme, Laura; Jorgensen, Steffen L.; Spang, Anja; Ettema, Thijs J. G.

Abstract

The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on H-2 exchange. However, there are no strong indications that modern eukaryotic H-2 metabolism originated from archaea or alphaproteobacteria. Here, we present evidence for the origin of H-2 metabolism genes in eukaryotes from an ancestor of the Anoxychlamydiales-a group of anaerobic chlamydiae, newly described here, from marine sediments. Among Chlamydiae, these bacteria uniquely encode genes for H-2 metabolism and other anaerobiosis-associated pathways. Phylogenetic analyses of several components of H-2 metabolism reveal that Anoxychlamydiales homologs are the closest relatives to eukaryotic sequences. We propose that an ancestor of the Anoxychlamydiales contributed these key genes during the evolution of eukaryotes, supporting a mosaic evolutionary origin of eukaryotic metabolism.

Published in

Science Advances
2020, volume: 6, number: 35, article number: eabb7258
Publisher: AMER ASSOC ADVANCEMENT SCIENCE

Authors' information

Stairs, Courtney W.
Uppsala University
Dharamshi, Jennah E.
Uppsala University
Tamarit Chuliá, Daniel
Uppsala University
Tamarit Chuliá, Daniel
Wageningen University and Research
Tamarit Chuliá, Daniel
Swedish University of Agricultural Sciences, Department of Aquatic Sciences and Assessment
Eme, Laura
Universite Paris Saclay
Eme, Laura
Uppsala University
Jorgensen, Steffen L.
University of Bergen
Spang, Anja
Utrecht University
Spang, Anja
Uppsala University
Ettema, Thijs J. G.
Uppsala University
Ettema, Thijs J. G.
Wageningen University and Research

UKÄ Subject classification

Evolutionary Biology

Publication Identifiers

DOI: https://doi.org/10.1126/sciadv.abb7258

URI (permanent link to this page)

https://res.slu.se/id/publ/107812