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Research article - Peer-reviewed, 2021

Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?

Buemann, Benjamin; Marazziti, Donatella; Uvnas-Moberg, Kerstin;


Objectives Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients. Methods We searched for, retrieved, and commented on specific literature regarding multiple functions of oxytocin with a special focus on its modulation of inflammatory, immune, and restorative functions. Results Available data gathered in animals and humans support the anti-inflammatory properties of oxytocin. The multiple anti-inflammatory effects of oxytocin have been demonstrated in vitro and in vivo in various animal models and also in humans in response to intravenous infusion of oxytocin. Furthermore, oxytocin has been documented to activate several types of protective and restorative mechanisms and to exert positive effects on the immune system. Conclusions In addition, to being anti-inflammatory, it may be hypothesised, that oxytocin may be less suppressive on adaptive immune systems, as compared with glucocorticoids. Finally, by its restorative effects coupled with its anti-stress and healing properties, oxytocin may shorten the recovery period of the Covid-19 patients.


Oxytocin; inflammation; anti-inflammatory; immune system; restorative; Covid-19; clinical trials

Published in

The World Journal of Biological Psychiatry

2021, volume: 22, number: 5, pages: 387-398

Authors' information

Buemann, Benjamin
No organisation
Marazziti, Donatella
University of Pisa
Swedish University of Agricultural Sciences, Department of Animal Environment and Health

UKÄ Subject classification

Immunology in the medical area

Publication Identifiers


URI (permanent link to this page)