Comparative genomics highlights the importance of drug efflux transporters during evolution of mycoparasitism in Clonostachys subgenus Bionectria (Fungi, Ascomycota, Hypocreales)

Abstract

Various strains of the mycoparasitic fungal speciesClonostachys roseaare used commercially as biological control agents for the control of fungal plant diseases in agricultural crop production. Further improvements of the use and efficacy ofC. roseain biocontrol require a mechanistic understanding of the factors that determines the outcome of the interaction betweenC. roseaand plant pathogenic fungi. Here, we determined the genome sequences of 11Clonostachysstrains, representing five species inClonostachyssubgenusBionectria, and performed a comparative genomic analysis with the aim to identify gene families evolving under selection for gene gains or losses. Several gene families predicted to encode proteins involved in biosynthesis of secondary metabolites, including polyketide synthases, nonribosomal peptide syntethases and cytochrome P450s, evolved under selection for gene gains (p

Keywords

antagonism; biological control; Clonostachys; membrane transporter; mycoparasitism; xenobiotics

Published in

Evolutionary applications
2021, volume: 14, number: 2, pages: 476-497
Publisher: WILEY

SLU Authors

• Broberg, Martin

  • Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
    

• Dubey, Mukesh

  • Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
    

• Iqbal, Mudassir

  • Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
    

• Gudmundsson, Mikael

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

• Ihrmark, Katarina

  • Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
    

• Jensen, Dan Funck

  • Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
    

• Brandström Durling, Mikael

  • Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
    

• Karlsson, Magnus

  • Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
    

Associated SLU-program

SLU Plant Protection Network
AMR: Fungus

Global goals (SDG)

SDG2 Zero hunger
SDG3 Good health and well-being

UKÄ Subject classification

Evolutionary Biology

Publication identifier

• DOI: https://doi.org/10.1111/eva.13134

Permanent link to this page (URI)

https://res.slu.se/id/publ/108131