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Review article - Peer-reviewed, 2020

Tidying-up the plant nuclear space: domains, functions, and dynamics

Santos, Ana Paula; Gaudin, Valerie; Mozgova, Iva; Pontvianne, Frederic; Schubert, Daniel; Tek, Ahmet L.; Dvorackova, Martina; Liu, Chang; Fransz, Paul; Rosa, Stefanie; Farrona, Sara


Understanding how the packaging of chromatin in the nucleus is regulated and organized to guide complex cellular and developmental programmes, as well as responses to environmental cues is a major question in biology. Technological advances have allowed remarkable progress within this field over the last years. However, we still know very little about how the 3D genome organization within the cell nucleus contributes to the regulation of gene expression. The nuclear space is compartmentalized in several domains such as the nucleolus, chromocentres, telomeres, protein bodies, and the nuclear periphery without the presence of a membrane around these domains. The role of these domains and their possible impact on nuclear activities is currently under intense investigation. In this review, we discuss new data from research in plants that clarify functional links between the organization of different nuclear domains and plant genome function with an emphasis on the potential of this organization for gene regulation.


3D Chromatin organization; chromocentres; gene expression; liquid-liquid phase separation (LLPS); nuclear domains; nuclear bodies; nucleolus; nuclear periphery; telomeres; topologically associated domains (TADs)

Published in

Journal of Experimental Botany
2020, volume: 71, number: 17, pages: 5160-5178

Authors' information

Santos, Ana Paula
Universidade Nova de Lisboa
Gaudin, Valerie
Universite Paris Saclay
Mozgova, Iva
University of South Bohemia Ceske Budejovice
Pontvianne, Frederic
Universite Perpignan Via Domitia
Schubert, Daniel
Free University of Berlin
Tek, Ahmet L.
Omer Halis Demir University
Dvorackova, Martina
Masaryk University Brno
Liu, Chang
University of Hohenheim
Fransz, Paul
University of Amsterdam
Swedish University of Agricultural Sciences, Department of Plant Biology
Farrona, Sara
National University of Ireland (NUI) Galway

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